Nothing is known about Colby's life prior to or as the outbreak began, except the fact that she is 32 years old and was a housewife.
Colby is one of the members of Jeremiah's group that get trapped in his Church. After being rescued from the herde of walkers by Lilly and the Woodbury survivors, she becomes a member of Woodbury. Jeremiah listed Colby, as being best suited to be part of the foraging team in Woodbury, as he hands Lilly a chart of the members of his groups best attribute, age and occupation. Later, Colby along with Rose and Cailinn butcher a couple of rabbits, deep fry them and serve them around to the residents of Woodbury.
After the Church group finally decides to all be part of the mass suicide in Woodbury to join with God, Colby is one of the females of the church group that prepare the sacramental food and drink back in the kitchen. After the idea of taking their lives fails, as Bob switched out the poison with water, Stephen blows the Woodbury gates as part of the plan, to let the undead in. However, as they failed to take their own lives, the Church group scatters as the horde arrives in Woodbury.
- Killed By
After Stephen blows the gates to Woodbury. Colby, Cailinn and Rose try hiding in the back of the Dew Drip Inn. However the walkers get through the service entrance and devour the women on the kitchen floor.