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The highway is seen in the Video Game where Lee Everett is handcuffed in the back of a police car, being taken to the Meriwether County Correctional Facility after being convicted of killing a state senator. Lee and the police officer have a conversation about Lee's past and the experiences of the police officer. Lee witnesses several police cars and SWAT teams driving on the opposite boulevard of the highway heading towards the city since reinforcements were being called in to control the situation and chaos (such as rioters) when his police car hits a walker that wanders onto the highway. The Police Officer loses control of the vehicle, swerves off the road and crashes the car.
While driving along the highway, Rick was low on gasoline. He stopped at the Campbellton Fairburn Road (Hwy 92) and Cascade Palmetto Highway traffic intersection, where a couple of abandoned vehicles, some overturned and burned, lay in ruins. Descending down a hill, Rick reached a makeshift camp consisting of tents and hundreds of cars. Children's toys, clothes, lawn chairs, luggage and other supplies littered the campground, along with a couple of decaying motorists in their vehicles.
Making his way through the maze of cars, Rick reached the gas station, only to find a sign labeled "NO GAS". He heard a shuffling noise and watched from under a car a child pick up a teddy bear. Thinking he had found a survivor, he rushed out and called out to the blonde girl in a robe, identifying himself. The girl stopped walking and turned around to reveal a partially eaten face and bloodstained chest. She lunged at Rick, leaving him no choice but to shoot the undead girl.
After completely running out of fuel on the road, he took out a gas can and looked for more gasoline. He reached a house along the road. He shouted out to the house, asking for gas. With no response, he peered in the windows to find a murder-suicide scenario: the farmer had shot his wife with a shot gun and written "GOD FORGIVE US" on the wall in blood, before committing suicide himself. Disturbed, Rick retreated, but found a horse nearby on the pasture, after checking on the couple's truck, which has no keys in the ignition or above the visor. Saddling up on the horse, they rode towards the city of Atlanta.
Summer - finding no gas at the gas station, Rick mistook Summer as a regular child when it turned out she is also a walker.
Police Officer - After the car accident, the police officer is overrun and attacked by walkers.