Not much is known about Jesse's life prior to or as the outbreak began, except that she had a brother named Tom and a mother and father.
Jesse survived in a subway tunnel alongside her family and dozens of other survivors. At some point, her father left the camp temporarily, but after failing to return when promised, her mother departed soon after to search for him, only to vanish herself. With Tom now the sole guardian of Jesse, the two kept hope alive that their parents would eventually return. Sometime after losing both of their parents, chaos erupted at the tunnel camp, causing the siblings to flee with Jesse dropping her stuffed rabbit as a result. Jesse's whereabouts after this event are unknown.
Daryl finds a note left by Tom to his father. He tells his father that their mother went missing and that he will take care of his sister now that they are on their own.
This list shows the victims Jesse has killed:
- Possibly numerous counts of zombies
- "Acheron: Part II" (Photograph)
- The stuffed rabbit seen in "Acheron: Part I" used to belong to Jesse.