Nothing is known about Luisa's life prior to or as the outbreak began, except that she has a mother and a brother.
Luisa doesn't directly appears during the cutscenes, but it is known that she was escaping from walkers alongside Michelle and Wesley, by going through a bridge. They encounters an unnamed survivor who doesn't appear to have peaceful intention, but they manage to get away and to go across the bridge.
Luisa first appears alongside her mother and brother, trying to survive while they are chased by both the Whisperers and the walkers. Later on, Luisa and her family are unwillingly recruited to the Whisperers.
- Whisperers 1
- Whisperers 3