Ponzio was born in New York City and graduated from Georgia State University. As of the late 1990s, Ponzio began appearing in supporting guest roles on television series.
Melissa co-hosts and performs in The Goods Variety Show and is active in The Goods Youth Foundation. She is proud to make kids laugh while showing them how to find "The Goods in themselves".
Melissa spends her down time as a rock star.
- Mary and Martha
- Justice for Natalee Holloway
- Warm Springs
- The Greenskeeper
- Atlanta Blue
- Teen Wolf