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Depression is a recurring theme in The Walking Dead. It is an emotion felt by characters in a period of time accompanied by feelings of hopelessness and inadequacy. It is much more common in this apocalyptic world where death is everywhere.
Carol becomes depressed for a long period of time after seeing Tyreese cheat on her with Michonne. This depression eventually leads to her suicide. (Issue 21, Issue 41)
Sophia goes through a short state of depression after her mother commits suicide. (Issue 41)
Lee Everett faces depression throughout the game about his brother, parents, and his ex-wife, having nightmares about what happened and showing signs of sadness. (Season One)
Clementine often faces depression when wondering whether her parents are alive or not. (Season One)
Doug/Carley go through a small depression after the loss of one or the other, due to having a crush on the other. (A New Day)
Lilly goes through a state of depression after the death of her father, Larry, and holds it against Kenny and Lee. (Determinant)(Starved For Help)
When Philip Blake loses his daughter, he goes through a great bout of depression and begins feeding her zombified corpse human flesh. (Rise of the Governor)
Andrea Harrison goes through a severe state of depression after the death of her sister, Amy. (Vatos)
Carol Peletier goes through a short state of depression after the death of her husband, Ed. (Vatos)
Dr. Jenner goes through a deep state of depression after the loss of his wife, his work, and all that he cares about. (Season 1)
T-Dog informs Dale Horvath about how he feels endangered due to being the only African-American in the group, causing him to feel depressed. (Bloodletting)
Hershel Greene becomes extremely depressed and begins drinking heavily again after the realization that nothing will be the same after the death of his friends, family, and neighbors at the hands of Rick Grimes' group, led by Shane Walsh. (Nebraska)
Carol goes through a brief state of depression after the loss of her daughter, Sophia, but overcomes it once she starts believing that she is in a better place and won't have to deal with the apocalyptic world anymore. (Nebraska)
Rick goes through a brief moment of depression after the death of his best friend, Shane. (Better Angels)
The group goes through a state of depression after the loss of Hershel's farm, as it was thought to be a safe haven. (Beside the Dying Fire)
Rick suffers a mental breakdown after the death of Lori. (Say the Word)
The Governor falls into a suicidal, apathetic depression after his daughter Penny is killed and he guns down his own people after a failed prison assault. (The Suicide King)
Morgan suffers a mental breakdown similar to Rick's after the loss of his son. (Clear)
Daryl Dixon goes through a quick but severe state of depression after finding his brother Merle as a walker and having to put him out of his misery. (This Sorrowful Life)
Lizzie Samuels becomes depressed after the death of her father and becomes more distraught after learning that someone had killed a walker called Nick. (Infected)
Bob suffers from depression due to losing two camps and deals with it by drinking. (Season 4)
Rick and his son Carl are devastated when they discover Judith's empty bloody carrier, both assuming she was devoured by walkers during the prison assault. (Too Far Gone)
Abraham Ford goes through depression after learning that Eugene Porter lied about being a scientist and knowing how to stop the outbreak. (Crossed)
Sasha becomes depressed after Bob's death. (Crossed)
Sasha, Daryl, and Maggie are shown to be depressed following the deaths of Beth and Tyreese. (Them)
Enid is depressed at the memory of her parents. (Remember)
Carol, Lydia and many others became depressed after losing their loves ones. (The Storm)
Mercer attempts to get his sister to claim depression as part of her defense for her role in Sebastian Milton's death. However, she refuses to go through with it. (Variant)
The Clark family were depressed after the death of their father/husband before the outbreak.
Alicia becomes deeply saddened after her boyfriend Matt is bitten and is forced to leave him at the demand of Madison and Travis. She shows signs of sadness again after seeing her zombified neighbor Susan and realizing that Matt may be just like her. (So Close, Yet So Far, The Dog)
Patrick becomes depressed when he comes home from the airport to find his wife as a walker and moments later, she is shot in the head by soldiers before she bit him. (The Dog)
Doug is upset and scared of being screened by medical personnel. (Not Fade Away)
Bethany Exner becomes depressed after having to euthanize her patients during the downfall of the medical center. (The Good Man)
Daniel and Ofelia Salazar grieve over the loss of Griselda Salazar. (The Good Man, Season 2)
Travis and Chris become depressed after Elizabeth's death, with Chris displaying animosity towards his father for killing her. (The Good Man, Monster)
Victor Strand becomes depressed over losing Thomas Abigail and considers committing suicide. (Sicut Cervus)
Ofelia experiences depression and hopelessness over the supposed death of her father Daniel after the fire at the Abigail estate. (Los Muertos, Do Not Disturb)
John Dorie becomes depressed after leaving the Pioneers, contemplating suicide. (The Door)
Following the death of their son, both Dwight and Sherry have become depressed and suicidal. Dwight begs what appears to be a hallucination of Daryl Dixon to kill him and later plans to die fighting off a large herd of walkers overrunning the Sanctuary to buy June, Sherry and Odessa Sanderson time. However, Sherry locks Dwight up, believing that PADRE needs him more. When trapped under a collapsed fence, Sherry appears to give up fighting and accept her fate before Dwight rescues her and they confront each other about their problems while fighting the herd together. The entire ordeal ultimately causes Dwight and Sherry to find a new hope for the future. (Sanctuary)
In his messages to Sandra, Joe mentions that, before the outbreak, his sister thinks that he's too depressed and is forcing him to see a therapist. (Evie / Joe)
Karina becomes depressed and suicidal when she thought that Paul had died. She asks Gale Macones to kill her with a lethal injection. (The Oath)
Jason Riley becomes depressed and suicidal after the death of his family. However, Teddy finds him as he is about to commit suicide and convinces Riley to stop. (This Ain't It)
Summer, after the loss of her parents, becomes depressed and runs away, later being infected and reanimating. (Social Game)
Ed is saddened by seeing his cousin become a walker and having to kill her, he later tells the player that he sees no hope for the group in the future. (Social Game)