Nothing is known about Tisha's life prior to or as the outbreak began.
Nothing is known about Tisha's life after the apocalypse, except that she joined Carver's community, and rose to the status of a guard.
Tisha is first seen when she brings Clementine back to the yard after she spoke with Carver. The next day she is seen guarding the main room of Howe's Hardware along with Hank and Russell (Determinant). Later she is seen on the roof of the store defending the community from the herd of walkers.
Tisha along with other community members are seen on the roof of Howe's Hardware defending the community from the herd of walkers. She and the others are last seen being cornered by the walkers on the roof. Their fates remain unknown.
This list shows the victims Tisha has killed: