- Mr. Siggard had possibly shot his wife and then killed himself, as an act of desperation. (Days Gone Bye)
- Rick Grimes almost shoots himself when he is surrounded by walkers under a tank until he saw the open hatch on the floor of the tank. (Days Gone Bye)
- Dr. Edwin Jenner, having lost all hope, decides to die in the destruction of the CDC with Jacqui joining him. Andrea Harrison initially tries to join them, but she is talked out of it by Dale Horvath. (TS-19)
- Rick discovers the body of a man who had committed suicide in a tent in the woods near the Vehicle Jammed Highway. (What Lies Ahead)
- Daryl and Andrea encounter a man who had hung himself after getting bitten but had still turned as he didn't destroy his brain. Daryl reluctantly puts him down in exchange for an answer from Andrea about her own suicidal feelings. (Bloodletting)
- After witnessing her zombified mother and half-brother get shot, Beth Greene loses hope in the world and tries to commit suicide by slashing her own wrists. (18 Miles Out)
- In order to prevent herself from turning, Andrea choses to shoot herself. (Welcome to the Tombs)
- Clara commits suicide by stabbing herself in the abdomen with her knife, so that she could turn into a walker and be with her undead husband, Eddie. (30 Days Without An Accident)
- Big Tony and his employees enter into a suicide pact at some point after the outbreak with Tony hanging himself and the other three drinking antifreeze. While looking for a battery at Big Tony's Express Mart, the four are found reanimated and put down by Daryl, Michonne and Bob Stookey. While their suicide disgusts Daryl, Bob is more sympathetic to their plight in the world that they live in and he suggests that the four wanted to go out as they had lived: together. (Indifference)
- The Governor is sitting at the campsite he, along with Caesar Martinez and Shumpert, set up by the Military Outpost. A female walker approaches him. She falls into the fire and proceeds to crawl towards him, but he does not react. In a state of clear depression and nihilism, Philip didn't care what happened to him at the moment and was ready for his ticket to get punched. This is until Martinez comes up and shoots the walker for him. (Live Bait)
- The Governor is ready to give up and falls to the ground. Whether he's ran over, eaten by a walker or shot, he was ready to die. That is until he notices Meghan watching him from a window. (Live Bait)
- During the outbreak, Bill Jenkins commits suicide by shooting himself in the head. However, as he had failed to destroy his brain, he reanimates. (Live Bait)
- Joan opens her recently amputated arm wound with scissors to prevent further rape from Gorman. She reanimates and is later put down by Dawn Lerner, but not before killing Gorman and Jeffries. (Slabtown)
- Abraham Ford almost commits suicide after he discovers his family dead, but stops to save Eugene Porter from walkers. (Self Help)
- Gabriel Stokes encounters a walker with a noose around his neck and trailing a broken rope, suggesting that the man had hung himself and the rope broke. (Conquer)
- Trapped on top of a dumpster by a herd of walkers, Nicholas shoots himself in the head after saying "Thank You" to Glenn for sparing his life. (Thank You)
- After losing her husband, Betsy, an Alexandria resident, slashes her own wrists, killing herself. (Now)
- Frankie and Tanya claim that Amber wants to commit suicide in order to get Eugene to make cyanide pills for them to use against Negan. However, after deducing the truth, Eugene refuses to give them the pills. (Hostiles and Calamities)
- Sasha Williams, in order to avoid being used against her friends by Negan, kills herself by taking a cyanide tablet given to her by Eugene. (The First Day of the Rest of Your Life)
- After Carl gets bit by a walker while helping Siddiq, he shoots himself to prevent himself from turning moments after giving his final goodbyes to Rick and Michonne. (Honor)
- After the death of Henry, Lydia attempts suicide by almost letting a walker bite her on the arm and telling Carol to kill her. (The Storm)
- Ezekiel contemplates suicide over all the problems he's facing like losing loved ones, the Kingdom, the growing concern of the Whisperers and his thyroid cancer. (Silence the Whisperers)
- Michonne tells Ezekiel that early on in the apocalypse when she was alone, she wanted walkers to bite her at times. (Silence the Whisperers)
- After getting bitten, Earl Sutton decides to commit suicide by driving his head into a railroad spike that he hammers through a table rather than risking harm to the kids that he rescued from the destruction of the Hilltop. However, Earl fails to destroy his brain and reanimates anyways, forcing Judith Grimes to put him down instead. (Walk With Us)
- When a riot breaks out at the research facility on Bloodsworth Island over the food rations, Virgil locks everyone inside, not knowing his wife and children are there. With no hope of escape, Lisa hangs herself alongside her children and many other survivors. They are later put down by Michonne at the request of Virgil. (What We Become)
- After being wounded and surrounded, the Attacker commits suicide by blowing himself up with a grenade. (Home Sweet Home)
- After being surrounded by walkers and with Maggie and the others unwilling to help him, Gage stabs himself twice in the heart, killing himself before his corpse is devoured by the herd. Gage reanimates shortly thereafter, but he is eventually put down by Gabriel with a shotgun blast to the head. (Acheron: Part II)
- Terrified about what might happen to his family if he talks, Wilson commits suicide by stabbing himself through the neck. (Outpost 22)
- Pamela Milton tries to commit suicide after being overthrown by feeding herself to a zombified Lance Hornsby. However, Maggie shoots Lance in the head, keeping Pamela from taking the easy way out rather than being imprisoned for her crimes. (Rest in Peace)
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