Washington, D.C. was the capital of the United States of America. It served as the center for the three branches of the federal government, as well as a number of museums and historical monuments.
When the outbreak began, the military immediately took control of D.C. and ordered an evacuation of key personnel only. Members of Congress and other people of the political circuit, such as Deanna Monroe and herfamily and Aaron and his boyfriend Eric, were the first people to evacuate to safe-zones outside of the city while civilians, including Paula, were still in D.C. awaiting further instruction. As the military either deserted the city or were overrun, D.C. was left for the dead.
Some of the safe-zones around D.C. were established in the suburban community of Alexandria, Virginia as well as the historic Barrington House in the deep woods in the south of Virginia.
Chase tells B.J. that he is heading to Cynthiana, Kentucky to join his sister and a group she is a part of that is forming a caravan to Washington, D.C. and leaving at dawn. Though Chase offers for B.J. to join him, he refuses.
When Chase tries to escape with Kelly, they are confronted by B.J. who reveals Chase's plan to Kelly and makes Chase choose between making the trip in one of his trucks and leaving Kelly behind or trying to save Kelly and not getting the truck. After Kelly kills B.J., the two escape in one of the trucks, unfortunately low on gas, to try to reach the caravan in time to go to Washington.
Eugene Porter claimed that the remnants of the U.S. government were apparently in the city, as they were communicating with him via satellite phone from Houston, Texas asking him to go there to cure the walker virus. It was later revealed to be false.
Approximately three and a half years after the outbreak, Washington D.C. lays in ruins, with extensive damage and overgrowth to much of its infrastructure, including the Capitol Building and the Washington Monument. Members from Alexandria, the Hilltop, the Kingdom, and Oceanside journey into the city to acquire farming tools from an abandoned museum.