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The road was a back lane in rural Georgia that is located in a dense forest next to the main highway. The road was most likely used by farmers and locals who lived in the area.
When Wyatt and Eddie are seen driving away from Nate in his pick-up truck after what is hinted that their camp was raided by a group, they pull off the main highway and onto Yewberry Road giving Wyatt and Eddie the opportunity to evade Nate and hide from him in the woods. After some conversation between the two, Eddie runs over Clyde, causing Wyatt and Eddie to have an argument about who goes and investigates whether or not it was a walker. They decide by playing rock, paper, scissors and either Wyatt or Eddie will go out to investigate. If Eddie goes, Nate finds Wyatt in the car and causes Wyatt to abandon Eddie; if Wyatt goes, and after finding Clyde, Eddie abandons Wyatt after being attacked by Nate, leaving him running off into the forest.